Research Models and Services
|
|||
|
Research Models and Services
|
||
|
Discovery Services: Oncology Research Services Using various in vitro and in vivo tumor models, Charles River Laboratories’ Oncology Services are available to help customers evaluate novel anticancer therapies. Multiple test agents can be screened to ascertain the most active agent, detect optimal dose levels, and determine appropriate dose regimens for your compounds. We offer xenograft and syngeneic murine models, bearing tumor cell lines that are either obtained from commercial sources or provided to us directly from the customers. Our research scientists will also work closely with our customers to develop detailed study protocols to meet their project goals. Together with an impressive line of complimentary service offerings within Research Models and Services, Preclinical Services, and Clinical Services, Charles River’s global infrastructure, harmonized approach, and commitment to quality allow us to provide unparalleled service in the field of cancer research. In vitro Compound Efficacy Testing This service involves the evaluation of cell proliferation and cell death in response to test article administration in cultured human or murine tumor cell lines. In vivo Tumor Growth Studies Most frequently, tumor cells are implanted via subcutaneous injection into the flank of nude mice.
These models provide a consistent and reproducible tool for evaluating tumor cell growth, as well as permit easy access to the mass for tumor treatment and ultrasound evaluation. Metastatic tumor incidence can be monitored through radiography, high-resolution ultrasound imaging, and necropsy. Once the implanted tumors reach a predetermined volume, we can transport the animal models to our customers, or perform compound efficacy studies under contract. Compound Efficacy Studies In an appropriate animal model, one or more therapeutic compounds may be administered to assess efficacy against tumor induction, latency, proliferation, and metastasis. Customers have the option to receive raw data and/or analyzed data at the completion of a study. Ancillary laboratory services such as necropsy, histopathology, and molecular phenotyping (i.e., mRNA and protein expression patterns) are also available to help maximize data capture. Tissue Biomarkers To further characterize tumor models, quantitative PCR-based expression testing and immunohistopathology can determine effects on key cellular processes, such as cell proliferation, cell death, and angiogenesis. Quantitative analysis of biomarker expression can help define mechanism of action for targeted therapeutics and assess their efficacy. |
What's New |
|
Charles River Home | Careers | Humane Care | Events | News Room | Investor Relations | Site Index | Contact |
Copyright ©
Charles River Laboratories, Inc. All Rights Reserved | Data Privacy Policy |
